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Pathological characteristics of triple negative breast cancer phenotype in a cohort of Sri Lankan females

Authors:

G V S Wathuge ,

Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe, Buckinghamshire HP11 2TT, GB
About G V S
Department of Cellular Pathology
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N V I Ratnatunga

Faculty of Medicine, University of Peradeniya, LK
About N V I
Department of Pathology
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Abstract

Introduction: Breast cancer is the commonest cancer among Sri Lankan women. Triple negative is a type of breast cancer that is negative for expression of oestrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor 2 receptors (HER 2).

Objective: To identify the pathological characteristics of triple negative breast cancer phenotype in a group of Sri Lankan women.

Method: 200 cases of diagnosed breast cancers were analysed to determine the prevalence of triple negative breast cancers. All the slides were re-examined histologically to find out whether there were specific morphological features in the triple negative group when compared with the ER/PR positive HER 2 negative group, ER/PR negative HER2 positive group and ER/PR positive HER2 positive group.

Results and conclusion: The prevalence of triple negative breast cancer in the study group was 36%. The mean age affected by this tumour category was 49.5 years. The commonest age group affected was 41-50 years. The commonest histological type in all categories was invasive ductal carcinoma. A significant number of triple negative tumours were histologically Grade 3 compared to the ER/PR positive HER2 negative group. The mean tumour size was 2.73 cm. Although the percentage of triple negative tumours among the lymph node stages was similar, a statistically significant number of triple negative tumours was in stage 3 and showed tumour necrosis. The triple negativity was also associated with a lymphocytic reaction at the host tumour interface and infiltrative margins. Triple negative status showed a negative association with skin and nipple invasion, lymphovascular invasion and an in-situ component.

How to Cite: Wathuge, G.V.S. & Ratnatunga, N.V.I., (2016). Pathological characteristics of triple negative breast cancer phenotype in a cohort of Sri Lankan females. Journal of Diagnostic Pathology. 10(2), pp.21–31. DOI: http://doi.org/10.4038/jdp.v10i2.7678
Published on 08 Jun 2016.
Peer Reviewed

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