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Original article

Juvenile ossifying fibroma: an analysis of clinico-pathological features in a case series with a literature review

Authors:

H. G. Ruwandi. N. Weerasinghe,

Mahiyangana Base Hospital, Mahiyangana, LK
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Pubudu. C. Wijesuriya,

Mahiyangana Base Hospital, Mahiyangana, LK
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Primali. R. Jayasooriya

University of Peradeniya, LK
About Primali. R.
Department of Oral Pathology, Faculty of Dental Sciences
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Abstract

Juvenile Aggressive Ossifying Fibroma (JAOF) is divided into two entities namely Juvenile Psammomatoid Ossifying Fibroma (JPOF) and Juvenile Trabecular Ossifying Fibroma (JTOF). JAOFs are aggressive but benign tumours that require clinico-pathological correlation to arrive at the definitive diagnosis. We report nine new cases of JPOF and 6 cases of JTOF with a brief review of the literature to aid correct diagnosis of these two different entities. According to the clinico-pathological analysis both JPOF and JTOF had occurred in children and adults, with a mean age of 28.6 years and 21 years at presentation respectively. JPOF showed a male predilection while equal gender distribution was observed in JTOF. Both tumours occurred most often in the mandible. Regarding the histopathological features all tumours were unencapsulated. All cases of JPOF showed presence of psammoma bodies which can be considered as a main diagnostic feature. JTOF showed osteoid and immature woven bone trabeculae. Osteoblastic rimming was commonly observed among JTOF but absent in JPOF. Other histopathological features did not show any striking difference between the two lesions. In conclusion, the term “Juvenile aggressive ossifying fibroma” is a misnomer as it can occur in adults as well. Therefore, the word “Juvenile” should be excluded when renaming the tumour which is a “need of the hour”. Further, the study demonstrates the use of demographic, radiological and histopathological features with clinico-pathological correlation to diagnose and exclude mimics of JPOF and JTOF.
How to Cite: Weerasinghe, H.G.R.N., Wijesuriya, P.C. & Jayasooriya, P.R., (2016). Juvenile ossifying fibroma: an analysis of clinico-pathological features in a case series with a literature review. Journal of Diagnostic Pathology. 11(2), pp.14–21. DOI: http://doi.org/10.4038/jdp.v11i2.7705
Published on 21 Dec 2016.
Peer Reviewed

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