Start Submission Become a Reviewer

Reading: Prevalence, clinicopathological characteristics and short term survival of triple negative a...

Download

A- A+
dyslexia friendly

Research Paper Abstracts

Prevalence, clinicopathological characteristics and short term survival of triple negative and basal like breast carcinoma in a cohort of Sri Lankan patients

Authors:

H. D. Wijesinghe ,

University of Colombo, LK
About H. D.
Faculty of Medicine
X close

P. Thuvarakan,

University of Colombo, LK
About P.
Faculty of Medicine
X close

G. K. Wijesinghe,

University of Colombo, LK
About G. K.
Faculty of Medicine
X close

J. Fernando,

National Hospital of Sri Lanka, LK
X close

U. Senarath,

University of Colombo, LK
About U.
Faculty of Medicine
X close

M. D. S. Lokuhetty

University of Colombo, LK
About M. D. S.
Faculty of Medicine
X close

Abstract

Introduction

Information on triple-negative (TNBC) and basal-like (BLBC) breast carcinoma (BCa) is limited in South-Asia. We aimed to determine the prevalence and clinicopathological characteristics of TNBC and BLBC and shortterm survival of TNBC among a cohort of BCa patients.

 

Methodology

Clinicopathological characteristics and short term survival of 211 women with BCa treated at the National Hospital of Sri Lanka from 2012-2014 were analyzed, excluding postneoadjuvant chemotherapy cases. Immunohistochemistry for hormonal and HER2 receptors and basal markers (CK5/6, CK14, EGFR, 34βE12) were performed on TNBCs. Data was analyzed using chi-squared test, logistic and Cox-regression.

 

Results

Forty-five (21.33%) were TNBC (95%, CI=15.8%-26.86%), correlating with younger age (p=0.03), premenopausal state (p=0.047), negative lymph nodes (p=0.016), lower stage (p=0.011), higher Nottingham grade (p<0.001), higher nuclear grade (p<0.001), increased mitoses (p<0.001), absent tubule formation (p=0.001), moderate/extensive necrosis (p<0.001), moderate/severe lymphoid infiltrate at tumour edge (p=0.002), pushing margins (p<0.001), absent ductal carcinoma-in-situ (DCIS) (p<0.001) and absent/mild central desmoplasia (p<0.001). Younger age (p=0.05), higher nuclear grade (p=0.017), reduced tubular differentiation (p=0.049), increased tumour necrosis (p=0.022) and reduced vascular density (p=0.02) were TNBC associated on logistic regression. Of TNBCs 23(52.3%) were BLBCs (95%, CI=37.71%-66.89%). Only extensive necrosis significantly correlated with BLBC (p=0.011). TNBC was unassociated with reduced overall/disease free short-term survival in 142(67.3%) patients for whom follow-up data was available.

 

Discussion

TNBC prevalence was comparable to studies from the Indian-subcontinent, however, higher than in the West. Clinicopathological characteristics were similar. Lack of association with adverse short-term survival was possibly due to exclusion of postchemotherapy cases.

 

Conclusion

Triple negative breast carcinoma prevalence was 21.33%. Younger age, premenopausal status, low TNM stage, high tumour grade, necrosis, pushing margins, lymphoid infiltrate at tumour margin, absent DCIS and absent/mild central desmoplasia were predictive of triple negative breast carcinoma. Moderate/extensive necrosis in a tumour with this morphology was predictive of basal like breast carcinoma. Triple negative breast carcinoma was not predictive of adverse short-term survival.
How to Cite: Wijesinghe, H.D. et al., (2016). Prevalence, clinicopathological characteristics and short term survival of triple negative and basal like breast carcinoma in a cohort of Sri Lankan patients. Journal of Diagnostic Pathology. 11(2), p.53. DOI: http://doi.org/10.4038/jdp.v11i2.7723
Published on 21 Dec 2016.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus