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Comparison of grading systems of mucoepidermoid carcinoma and the impact on patient survival

Authors:

PR Jayasooriya ,

University of Peradeniya, LK
About PR
Department of Oral Pathology, Faculty of Dental Sciences
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PRCL Karunathilake,

University of Peradeniya, LK
About PRCL
Department of Oral Pathology, Faculty of Dental Sciences
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BSMS Siriwardena,

University of Peradeniya, LK
About BSMS
Department of Oral Pathology, Faculty of Dental Sciences
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EAPD Amaratunga,

University of Peradeniya, LK
About EAPD
Department of Oral Pathology, Faculty of Dental Sciences
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AM Attygalla

University of Peradeniya, LK
About AM

Department of Oral Maxillofacial Surgery, Faculty of Dental Sciences

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Abstract

Objective: To grade MEC using the criteria of the Armed forces Institute of Pathology (AFIP), Brandwein point based system and Modified Healey qualitative analytic system and correlate the survival data with the grading obtained for each patient.

Method: Haematoxylin and eosin stained slides of 34 patients with MEC were used to grade the tumours according to the criteria specified in the three grading systems. Survival period in months and the outcome including if the patient had died due to disease or whether the patient is living with or without disease was obtained by sending a questionnaire to the patients/relatives of the patient.

Results: Statistically significant higher recurrence and poor survival rates could be observed in high grade MECs compared to low/intermediate grade tumours when MECs were graded according to AFIP (Recurrence rate - p=0.0036, survival - p=0.0067) and Modified Healey (Recurrence rate - p=0.031, survival - p=0.0067) system. However, no statistically significant differences could be demonstrated when the tumours were graded according to Brandwein classification (p>0.05).

Conclusion: The histopathological grade carries a high prognostic significance, when MECs are graded according to AFIP and Modified Healey classifications, while Brandwein system was unsuitable to predict the survival and prognosis of patients.

DOI: http://dx.doi.org/10.4038/jdp.v7i1.5595

Journal of Diagnostic Pathology 2012 (7); 1: 42-49

How to Cite: Jayasooriya, P. et al., (2013). Comparison of grading systems of mucoepidermoid carcinoma and the impact on patient survival. Journal of Diagnostic Pathology. 7(1), pp.42–49. DOI: http://doi.org/10.4038/jdp.v7i1.5595
Published on 23 May 2013.
Peer Reviewed

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